Sickle Cell Disease Research

Our team participates in several national research studies with other sickle cell specialists around the country.  In recent years, this has included:

  • The Silent Cerebral Infarct Multicenter Transfusion (SIT) Study
  • Protocol GLUSCC09-01 –A Phase III, Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study of L-Glutamine Therapy for Sickle Cell Anemia and Sickle Beta Zero Thalassemia – sponsored by Emmaus Medical, Inc.

Currently we are enrolling subjects in the DOVE Study, “Determining effects of platelet inhibition on vaso-occlusive events," Protocol H7T-MC-TADO, a Phase III, Double-Blind, Randomized, Efficacy and Safety Comparison of Prasugrel and Placebo in Pediatric Patients with Sickle Cell Disease. This study is sponsored by Eli Lilly and Company/Daiichi-Sankyo, Ltd.

We have recently received IRB approval to begin subject enrollment in the HU Prevent Study, “Hydroxyurea to Prevent CNS Complications of Sickle Cell Disease in Children."

Treatment Partnerships

We also partner with community organizations such as Turning Point, the Center for Hope and Healing to provide AYA educational and social activities throughout the year in addition to our annual week of summer camp known as Camp Courage for individuals aged 6-14 years. 

Clinical Trials


Division of Pediatric Hematology/ Oncology Sickle Cell Disease Program – At Children’s Hospital of St. Louis
One Children’s Place
St. Louis, MO 63110
Pediatric Care: (314) 454-6018 or (800) 678-5437

Hospital Hill Sickle Cell Disease Treatment – At Truman Medical Center
2301 Holmes Street
Kansas City, MO 64108
Adult Care: (816) 404-4290

Internal Medicine/ Hematology Center for Advanced Medicine – At Washington University in St. Louis
4921 Parkview Place Suite 7B
St. Louis, MO 63110
Adult Care: (314) 362-7578

St. Louis - Washington University/St. Louis Children's Hospital
A clinical trial to evaluate treatments using CD34 selected T-cell depleted allogeneic SCT for patients with Sickle Cell Disease